Age-related alterations in epicardial arteries of spontaneously hypertensive rats
| Autor: | Herbert Ichinose, I-li Chen, Robert D. Yates, John B. Saer |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Basement Membrane Spontaneously hypertensive rat Smooth muscle Internal medicine Age related Organelle medicine Extracellular Animals cardiovascular diseases Silver Methenamine business.industry Age Factors Muscle Smooth Anatomy Arteries Rats Coronary arteries Microscopy Electron medicine.anatomical_structure Endocrinology Hypertension cardiovascular system Female business Pericardium Artery |
| Zdroj: | Virchows Archiv. B, Cell pathology including molecular pathology. 36(1) |
| ISSN: | 0340-6075 |
| Popis: | Proximal portions of the left coronary arteries were examined microscopically in aging female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). The age-related intimal alterations in SHR were largely limited to endothelial cells, which demonstrated a proliferation of organelles (most notably Weibel-Palade bodies). In the media, degenerative alterations appeared to be most marked near the medio-adventitial junction. Compared to WKY and increasing with age, the media of the SHR epicardial artery demonstrated an accumulation of extracellular elements that included basement membrane-like material, collagen fibers and debris. Complex carbohydrates, as determined with the silver methenamine reaction, were noted to accumulate in a lamellar fashion. Smooth muscle cells demonstrated an age-related tendency (which was exaggerated in SHR) toward development of invaginations and irregular profiles. These observations indicate that age-related structural alterations in epicardial arteries of SHR are progressive, and they support the concept that structural alterations in SHR coronary arteries may represent accelerated aging phenomena. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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