Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation
Autor: | Jing Fu, Annan Liu, Shuwen Yang, Suyan Cao, Yan Zhang, Deping Liu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Stimulation Comorbidity CHOP Mice 0302 clinical medicine Atrial Fibrillation Medicine Endoplasmic Reticulum Chaperone BiP Incidence digestive oral and skin physiology food and beverages Atrial fibrillation Middle Aged Endoplasmic Reticulum Stress Immunohistochemistry Echocardiography 030220 oncology & carcinogenesis Molecular Medicine Original Article Female Disease Susceptibility medicine.symptom hormones hormone substitutes and hormone antagonists medicine.medical_specialty Normal diet Diet High-Fat high‐fat diet 03 medical and health sciences Internal medicine Animals Humans Heart Atria Obesity Aged Fibrillation Atrium (architecture) business.industry ATF6 Endoplasmic reticulum nutritional and metabolic diseases Cell Biology Original Articles Overweight medicine.disease Fibrosis Disease Models Animal 030104 developmental biology Endocrinology atrial fibrosis business Biomarkers |
Zdroj: | Journal of Cellular and Molecular Medicine |
ISSN: | 1582-4934 1582-1838 |
Popis: | Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High‐fat diet (HFD)‐induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD‐induced AF remains elusive. Human atrium samples were examined for the ERS activation test. C57BL/6J mice were divided into four groups, including the control group, the HFD group, the 4‐phenylbutyric acid (4‐PBA) group, and the HFD + 4‐PBA group. At the age of 4 weeks, the HFD group and the HFD + 4‐PBA group were given HFD to construct the obesity model, while the other two groups were given a normal diet (ND). Transesophageal programmed electrical stimulation was conducted to evaluate the AF inducibility and duration. Atrial fibrosis and ERS activation were also investigated.We found that CHOP and GRP‐78 protein were significantly higher in overweight patients than the controls (both P 0.05). The mice of the HFD group had significantly higher collagen volume fraction (CVF%) than the other groups (P |
Databáze: | OpenAIRE |
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