Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation

Autor: Jing Fu, Annan Liu, Shuwen Yang, Suyan Cao, Yan Zhang, Deping Liu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Stimulation
Comorbidity
CHOP
Mice
0302 clinical medicine
Atrial Fibrillation
Medicine
Endoplasmic Reticulum Chaperone BiP
Incidence
digestive
oral
and skin physiology
food and beverages
Atrial fibrillation
Middle Aged
Endoplasmic Reticulum Stress
Immunohistochemistry
Echocardiography
030220 oncology & carcinogenesis
Molecular Medicine
Original Article
Female
Disease Susceptibility
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
Normal diet
Diet
High-Fat
high‐fat diet
03 medical and health sciences
Internal medicine
Animals
Humans
Heart Atria
Obesity
Aged
Fibrillation
Atrium (architecture)
business.industry
ATF6
Endoplasmic reticulum
nutritional and metabolic diseases
Cell Biology
Original Articles
Overweight
medicine.disease
Fibrosis
Disease Models
Animal
030104 developmental biology
Endocrinology
atrial fibrosis
business
Biomarkers
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-4934
1582-1838
Popis: Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High‐fat diet (HFD)‐induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD‐induced AF remains elusive. Human atrium samples were examined for the ERS activation test. C57BL/6J mice were divided into four groups, including the control group, the HFD group, the 4‐phenylbutyric acid (4‐PBA) group, and the HFD + 4‐PBA group. At the age of 4 weeks, the HFD group and the HFD + 4‐PBA group were given HFD to construct the obesity model, while the other two groups were given a normal diet (ND). Transesophageal programmed electrical stimulation was conducted to evaluate the AF inducibility and duration. Atrial fibrosis and ERS activation were also investigated.We found that CHOP and GRP‐78 protein were significantly higher in overweight patients than the controls (both P 0.05). The mice of the HFD group had significantly higher collagen volume fraction (CVF%) than the other groups (P
Databáze: OpenAIRE
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