Supplementary Methods, Figures S1-S11, and References from A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist

Autor: Toshiya Inaba, Yoshio Hosoi, Yasushi Nagata, Kenji Kamiya, Mitsuru Nenoi, Atsushi Enomoto, Keiji Tanimoto, Chihiro Yanagawa, Yosuke Kawate, Shohei Ujita, Tatsuro Teraoka, Yurie Nishi, Akiko Sawa, Tetsuji Yamaguchi, Kaoru Tanaka, Shinya Ariyasu, Bing Wang, Shin Aoki, Megumi Sasatani, Ippei Takahashi, Akinori Morita
Rok vydání: 2023
Popis: Figure S1. 5CHQ suppresses etoposide-induced apoptosis in wt-p53-expressing cells; Figure S2. Effect of 5CHQ on p53's DNA-binding to CDKN1A and BBC3 promoter oligonucleotides; Figure S3. 5CHQ by itself activates p53-mediated transcription; Figure S4. Effect of 5CHQ on cell cycle distribution; Figure S5. MTD study of 5CHQ; Figure S6. The technique of SBI to avoid BM aplasia; Figure S7. Additional TBI experiments; Figure S8. Sixty-day survival test of C57BL/6 mouse after 20 Gy-SBI; Figure S9. Immunoblotting also revealed the transactivation-modulating activity of 5CHQ; Figure S10. Dose response of 5CHQ on etoposide-induced apoptosis in FM3A cells; Figure S11. 5CHQ relieves the decrease of the stem cell marker Lgr5 mRNA expression after SBI.
Databáze: OpenAIRE