Pharmacokinetic Characterization to Enable Medicine Use in Pregnancy, the Potential Role of Physiologically-Based Pharmacokinetic Modeling: A Regulatory Perspective
| Autor: | Paola Coppola, Essam Kerwash, Janet Nooney, Susan Cole, Siu Ping Lam |
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| Rok vydání: | 2020 |
| Předmět: |
Physiologically based pharmacokinetic modelling
medicine.medical_specialty Maternal Health Pharmacokinetic modeling Self Medication Models Biological Fetal Development Pharmacokinetics Pregnancy medicine Humans Pharmacology (medical) Dosing Intensive care medicine Medicine use business.industry Perspective (graphical) lcsh:RM1-950 Pregnancy Outcome medicine.disease lcsh:Therapeutics. Pharmacology Modeling and Simulation Perspective Female business Perspectives |
| Zdroj: | CPT: Pharmacometrics & Systems Pharmacology CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 547-549 (2020) |
| ISSN: | 2163-8306 |
| Popis: | It is generally recommended that use of medicines should be avoided during pregnancy, sometimes however use of a medicine is essential to safeguard the health of mother and baby. A very limited number of medicines are however specifically licensed for use in pregnancy. This article considers the potential of PBPK modelling as a predictive tool to investigate the expected systemic exposure of medicines in pregnant women and to support possible dosing adjustment to maintain efficacy. |
| Databáze: | OpenAIRE |
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