Predator-secreted sulfolipids induce fear-like defense responses in C. elegans
| Autor: | Ada Tong, Kevin P. Curran, Sreekanth H. Chalasani, Neelanjan Bose, Zheng Liu, Jagan Srinivasan, Amy K. Pribadi, Sarah G Leinwand, Frank C. Schroeder, Christopher D. Chute, Maro J. Kariya |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0303 health sciences
biology Ecology ved/biology ved/biology.organism_classification_rank.species Amphid Sensory system biology.organism_classification Cell biology 03 medical and health sciences Transient receptor potential channel Metabolic pathway 0302 clinical medicine Pristionchus pacificus Signal transduction Predator 030217 neurology & neurosurgery Caenorhabditis elegans 030304 developmental biology |
| Popis: | Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation. These sulfolipids are detected by four pairs of C. elegans amphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Specific abolishment of predator-evoked C. elegans responses by the anti-anxiety drug sertraline as well as functional homology of the delineated signaling pathways suggests a conserved or convergent strategy for managing predator threats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|