Detection of early cognitive impairment using AD8 in a young patient with stroke with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome: a case report
| Autor: | Wen Chen Chang, Wei-Jang Yen, I-Chieh Hsieh, Ta Shen Kuan, Pei Chun Hsieh, Yu Ching Lin, Shu-Min Chen, I-Ling Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Brain Infarction
medicine.medical_specialty CADASIL Leukoencephalopathy Diagnosis Differential Cognition Internal medicine Surveys and Questionnaires medicine Humans Cognitive impairment Stroke Receptor Notch3 medicine.diagnostic_test Receptors Notch General Neuroscience Magnetic resonance imaging CADASIL Syndrome Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Early Diagnosis Brain infarction Mutation Cardiology Physical therapy Female Geriatrics and Gerontology Differential diagnosis Psychology Cognition Disorders |
| Zdroj: | American journal of Alzheimer's disease and other dementias. 29(2) |
| ISSN: | 1938-2731 |
| Popis: | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is a hereditary disease resulting from NOTCH3 gene mutation. The clinical presentations include migraine, recurrent stroke, and cognitive impairment. The severity of cognitive impairment varies in different stages, and early recognition poses a challenge. A 47-year-old lady presented with chronic migraine and sudden onset of hemiparesis. Magnetic resonance imaging revealed compatible findings of CADASIL, which was confirmed by mutation analysis of NOTCH3 gene. Early cognitive impairment was detected by her score of 3 in Ascertain Dementia 8 (AD8) questionnaire and confirmed by detailed neuropsychological assessments. After 21 months of follow-up, deterioration in her cognition and ability to perform instrumental activities of daily living were significant with a follow-up AD8 score of 7. Ascertain Dementia 8 questionnaire is an easy and valid screening tool for early cognitive impairment in patients with CADASIL syndrome. |
| Databáze: | OpenAIRE |
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