The PDZ Protein Canoe/AF-6 Links Ras-MAPK, Notch and Wingless/Wnt Signaling Pathways by Directly Interacting with Ras, Notch and Dishevelled
| Autor: | Mary K. Baylies, Ana Carmena, Stephan Speicher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
MAPK/ERK pathway
MAP Kinase Signaling System Cell Biology/Neuronal Signaling Mechanisms PDZ domain Cell Biology/Cell Growth and Division Dishevelled Proteins lcsh:Medicine Genes Insect Wnt1 Protein Biology Models Biological Cell Biology/Cell Signaling Animals Genetically Modified Mesoderm 03 medical and health sciences 0302 clinical medicine Biochemistry/Cell Signaling and Trafficking Structures Developmental Biology/Developmental Molecular Mechanisms Animals Drosophila Proteins lcsh:Science Protein kinase A 030304 developmental biology Adaptor Proteins Signal Transducing chemistry.chemical_classification 0303 health sciences Multidisciplinary Receptors Notch Effector Developmental Biology/Morphogenesis and Cell Biology lcsh:R Wnt signaling pathway Signal transducing adaptor protein Phosphoproteins Cell biology Dishevelled Developmental Biology/Neurodevelopment Wnt Proteins chemistry Mutation ras Proteins lcsh:Q Drosophila Signal transduction 030217 neurology & neurosurgery Research Article Developmental Biology Signal Transduction |
| Zdroj: | PLoS ONE PLoS ONE, Vol 1, p e66 (2006) |
| ISSN: | 1932-6203 |
| Popis: | Over the past few years, it has become increasingly apparent that signal transduction pathways are not merely linear cascades; they are organized into complex signaling networks that require high levels of regulation to generate precise and unique cell responses. However, the underlying regulatory mechanisms by which signaling pathways cross-communicate remain poorly understood. Here we show that the Ras-binding protein Canoe (Cno)/AF-6, a PDZ protein normally associated with cellular junctions, is a key modulator of Wingless (Wg)/Wnt, Ras-Mitogen Activated Protein Kinase (MAPK) and Notch (N) signaling pathways cross-communication. Our data show a repressive effect of Cno/AF-6 on these three signaling pathways through physical interactions with Ras, N and the cytoplasmic protein Dishevelled (Dsh), a key Wg effector. We propose a model in which Cno, through those interactions, actively coordinates, at the membrane level, Ras-MAPK, N and Wg signaling pathways during progenitor specification. |
| Databáze: | OpenAIRE |
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