Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids
| Autor: | Saleh Alghamdi, Ali AlFaiz, Saleh Alrajhi, Khalid Al-Otaibi, Abdullah Alsuhail, Saad Alamri, Naji Aljohani, Nemer Abdulaziz Alotaibi, Dayel AlShahrani, Emad Kutbi, Habeeb Alhabeeb |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Central Nervous System obesity food intake gut hormones Appetite Review Overweight Bioinformatics Mice 0302 clinical medicine Glucagon-Like Peptide 1 Medicine Overeating Cause of death media_common Acetic Acid Nutrition and Dietetics diabetes Dipeptides Glucagon-like peptide-1 Ghrelin Butyrates Oxyntomodulin medicine.symptom Cholecystokinin lcsh:Nutrition. Foods and food supply neuropeptide Y media_common.quotation_subject 030209 endocrinology & metabolism lcsh:TX341-641 Hyperphagia Satiation Pancreatic Polypeptide Gastrointestinal Hormones 03 medical and health sciences Diabetes mellitus Animals Humans overweight business.industry Appetite Regulation medicine.disease Fatty Acids Volatile Obesity Gastrointestinal Tract 030104 developmental biology peptide tyrosine tyrosine glucagon-like peptide-1 Propionates business Energy Intake Energy Metabolism short chain fatty acids Food Science Hormone |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 481, p 481 (2021) |
| ISSN: | 2072-6643 |
| Popis: | We are currently facing an obesity pandemic, with worldwide obesity rates having tripled since 1975. Obesity is one of the main risk factors for the development of non-communicable diseases, which are now the leading cause of death worldwide. This calls for urgent action towards understanding the underlying mechanisms behind the development of obesity as well as developing more effective treatments and interventions. Appetite is carefully regulated in humans via the interaction between the central nervous system and peripheral hormones. This involves a delicate balance in external stimuli, circulating satiating and appetite stimulating hormones, and correct functioning of neuronal signals. Any changes in this equilibrium can lead to an imbalance in energy intake versus expenditure, which often leads to overeating, and potentially weight gain resulting in overweight or obesity. Several lines of research have shown imbalances in gut hormones are found in those who are overweight or obese, which may be contributing to their condition. Therefore, this review examines the evidence for targeting gut hormones in the treatment of obesity by discussing how their dysregulation influences food intake, the potential possibility of altering the circulating levels of these hormones for treating obesity, as well as the role of short chain fatty acids and protein as novel treatments. |
| Databáze: | OpenAIRE |
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