THE ROLE OF THE SUPEROXIDE DISMUTASE FOR PREDICTING LONG-TERM ADVERSE EVENTS IN PATIENTS WITH ACUTE CORONARY SYNDROME
| Autor: | Olga Barbarash, Evgeniya A. Schmidt, Anastasiya V. Osokina, Svetlana A. Berns, Alla V. Klimenkova, Olga A. Nagirnyak |
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| Rok vydání: | 2019 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Time Factors Myocardial Infarction Ventricular Function Left Superoxide dismutase Internal medicine Humans Medicine In patient Myocardial infarction Acute Coronary Syndrome Adverse effect Anamnesis Ejection fraction biology Superoxide Dismutase business.industry Incidence (epidemiology) Biochemistry (medical) General Medicine medicine.disease Medical Laboratory Technology Cardiology biology.protein business |
| Zdroj: | Russian Clinical Laboratory Diagnostics. 64:463-468 |
| ISSN: | 0869-2084 |
| Popis: | To study the relationship between the blood concentration of superoxide dismutase in at the end of the hospital period of acute coronary syndrome without ST-segment elevation (nonST-ACS) and the development of adverse events in the long-term follow-up period. 415 patients with nonST-ACS are included in the local register study. The follow-up period was 60 months. The blood concentration of superoxide dismutase (SOD) determined in 200 patients on the 10-13th day of hospitalization in addition to clinical procedures. Within five years after discharge in 178 (47 %) patients reported the development of adverse events. Patients with poor outcome were older, had a history of myocardial infarction (PICS), stenoses of extracranial arteries more than 30% and decreased left ventricular ejection fraction (LVEF). There were significant differences in the concentration of SOD10-13 day, which was lower in the patients with development of adverse cardiovascular events (p = 0.0003). Multivariate analysis identified the factors that are most strongly associated with the development of the adverse events during a 5-year follow-up period in patients with nonST-ACS: SOD blood concentration ≤ 175,4 ng / ml (OR-3,85; р=0,0008), myocardial infarction in anamnesis (OR-3,26; р=0,006), LVEF ≤ 52% (OR-2,8; р=0,035). The incidence of adverse cardiovascular events during five years follow-up in patients with nonST-ACS was 47 % of cases. Adverse factors associated with the development of an unfavorable outcome in the long-term period follow are: SOD blood concentration ≤ 175,4 ng / ml, myocardial infarction in anamnesis, LVEF ≤ 52%. |
| Databáze: | OpenAIRE |
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