The multifaceted roles of microRNAs in differentiation
| Autor: | Himani Galagali, John Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neurogenesis
Cellular differentiation Embryonic Development Cell fate determination Models Biological Article 03 medical and health sciences Developmental timing 0302 clinical medicine microRNA Animals Humans Caenorhabditis elegans 030304 developmental biology 0303 health sciences biology Cell Differentiation Cell Biology biology.organism_classification Embryonic stem cell Cell biology MicroRNAs Drosophila melanogaster Transcriptome 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Curr Opin Cell Biol |
| ISSN: | 0955-0674 |
| Popis: | MicroRNAs (miRNAs) are major drivers of cell fate specification and differentiation. The post-transcriptional regulation of key molecular factors by microRNAs contributes to the progression of embryonic and postembryonic development in several organisms. Following the discovery of lin-4 and let-7 in Caenorhabditis elegans and bantam microRNAs in Drosophila melanogaster, microRNAs have emerged as orchestrators of cellular differentiation and developmental timing. Spatiotemporal control of microRNAs and associated protein machinery can modulate microRNA activity. Additionally, adaptive modulation of microRNA expression and function in response to changing environmental conditions ensures that robust cell fate specification during development is maintained. Herein, we review the role of microRNAs in the regulation of differentiation during development. |
| Databáze: | OpenAIRE |
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