Diagnostic value of elevated CXCR4 and CXCL12 in neonatal sepsis
| Autor: | Mehmet Saldir, Tugce Kalayci, Oguzhan Babacan, Erkan Sari, Galip Erdem, Mustafa Kul, Turan Tunc, Ferhat Cekmez, Merih Cetinkaya, Kursat Fidanci, Tuncer Cayci, Sultan Kavuncuoglu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Receptors CXCR4 medicine.medical_specialty Chemokine CXCR4 Gastroenterology Sepsis Internal medicine medicine Humans Prospective Studies Receptor Neonatal sepsis biology Interleukin-6 business.industry Infant Newborn Obstetrics and Gynecology Venous blood bacterial infections and mycoses medicine.disease Chemokine CXCL12 ROC Curve Pediatrics Perinatology and Child Health Immunology biology.protein Female business Biomarkers |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 28:356-361 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Neonatal sepsis remains a major cause of morbidity and mortality in newborns. The chemokine CXCL12 and its receptor CXCR4 are now known to play an important role in inflammatory states. However, it is unclear how chemokines respond to late-onset neonatal sepsis.Patients were classified into the groups of septic and non-septic ones. Samples of venous blood were obtained from all septic and non-septic newborns at the beginning and within 48-72 h after initiation of treatment. Serum levels of CXCR4 and CXCL12 were measured.Concentrations of IL-6, CXCR4 and CXCL12 at the time of diagnosis were significantly higher in the septic neonates compared with the non-septic ones. Additionally, there were statistically significant differences in septic neonates between the first and the second levels of IL-6, CXCR4, CXCL12 and I/T ratio. ROC curve analyses revealed that IL-6, CXCR4, CXCL12 and I/T ratio resulted in significant AUC with respect to early identification of septic neonates. Univariate logistic regression analysis showed that increased IL-6, CXCR4 and CXCL12 were strong predictors of neonatal LOS.Serum CXCR4 and CXCL12 levels increase in septic neonates and that both chemokines decrease within 48-72 h of treatment. Serum concentrations of both chemokines represent promising novel biomarkers for neonatal sepsis. |
| Databáze: | OpenAIRE |
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