Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
| Autor: | Weida Tong, Sugunadevi Sakkiah, Tony Wang, Yuping Wang, Wen Zou, Huixiao Hong, Bohu Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis lcsh:Medicine Disease Review Endocrine Disruptors Bioinformatics metabolic syndrome Androgen receptor binding 03 medical and health sciences Prostate cancer Diabetes mellitus androgen receptor medicine Androgen Receptor Antagonists Endocrine system Animals Humans cancer business.industry lcsh:R Public Health Environmental and Occupational Health medicine.disease Androgen receptor 030104 developmental biology Receptors Androgen diabetes mellitus Androgens business androgenic activity compounds Hormone |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 15, Iss 1, p 25 (2017) International Journal of Environmental Research and Public Health |
| ISSN: | 1660-4601 |
| Popis: | Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer's disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus. |
| Databáze: | OpenAIRE |
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