Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma
| Autor: | Chin-Jung Hsu, Chia-Hsuan Chou, Hsiao-Chi Tsai, Shun-Fa Yang, Bin Wang, Hsiang-Lin Lee, Whei-Ling Chiang, Chih-Hsin Tang, Chen-Ming Su |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Carcinoma Hepatocellular Hepatocellular carcinoma Susceptibility Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency medicine Biomarkers Tumor Humans Genetic Predisposition to Disease Allele Allele frequency Aurora Kinase A Oncogene business.industry Liver Neoplasms AURKA Gene General Medicine Middle Aged medicine.disease digestive system diseases Single nucleotide polymorphism 030104 developmental biology 030220 oncology & carcinogenesis Case-Control Studies Cancer research Biomarker (medicine) Female business Research Paper AURKA polymorphisms |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at AURKA SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the AURKA gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC. |
| Databáze: | OpenAIRE |
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