Chlorcyclizine induction of cleft palate in the rat: Degradation of palatal glycosaminoglycans
| Autor: | C. T. G. King, A. L. Wilk, Robert M. Pratt |
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| Rok vydání: | 1978 |
| Předmět: |
Embryology
medicine.medical_specialty Norchlorcyclizine Health Toxicology and Mutagenesis Toxicology Piperazines Glycosaminoglycan chemistry.chemical_compound Chlorcyclizine Pregnancy Internal medicine Hyaluronic acid medicine Protein biosynthesis Animals Chondroitin sulfate Hyaluronic Acid Glycosaminoglycans Palate Chemistry Chondroitin Sulfates Abnormalities Drug-Induced DNA Anatomy In vitro Teratology Rats Cleft Palate Endocrinology Protein Biosynthesis Female Germ Layers Developmental Biology medicine.drug |
| Zdroj: | Teratology. 18:199-209 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420180205 |
| Popis: | Administration of the cleft palate teratogen chlorcyclizine or norchlorcyclizine to pregnant rats causes an alteration in glycosaminoglycans (GAGs) in embryonic palatal shelves. Pulse-chase experiments in vitro indicate that norchlorcyclizine enhances the degradation of hyaluronic acid and chondroitin sulfate but has little or no effect on their synthesis. These changes in GAGs are caused by concentrations of norchlorcyclizine that have no appreciable effect on DNA or protein synthesis. These findings suggest that degradation of palatal GAGs may be the primary biochemical defect responsible for the inhibition of palatal shelf elevation by norchlorcyclizine. |
| Databáze: | OpenAIRE |
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