Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020
| Autor: | Georg F. Hoffmann, Daniela Huzly, Andreas Peter, Linus Fritsch, Roland Elling, Peter Meissner, Philipp Henneke, Jürgen Grulich-Henn, Maria Zernickel, Thomas Iftner, Corinna Engel, Sven F. Garbade, Tessa Görne, Hans-Georg Kräusslich, Natalia Ruetalo, Maximilian Stich, Tina Ganzenmueller, Axel R. Franz, Dorit Fabricius, Ales Janda, Thomas Stamminger, Burkhard Tönshoff, Barbara Müller, Alexandra Nieters, Hartmut Hengel, Jonathan Remppis, Tim Waterboer, Benedikt Spielberger, Klaus-Michael Debatin, Kathrin Jeltsch, Andrea N Dietz, Anneke Haddad, Hanna Renk |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Microbiology (medical) Epidemiology Cross-sectional study Secondary infection serology Infectious and parasitic diseases RC109-216 respiratory infections children Seroepidemiologic Studies Germany Pandemic antibodies Humans Medicine viruses Transmission risks and rates Child Disease burden business.industry Transmission (medicine) SARS-CoV-2 Research transmission households COVID-19 Odds ratio zoonoses Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children Southwest Germany May–August 2020 Cross-Sectional Studies Infectious Diseases coronavirus disease business Demography severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Emerging Infectious Diseases, Vol 27, Iss 12, Pp 3009-3019 (2021) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = 60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden. |
| Databáze: | OpenAIRE |
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