Peritoneal Dialysis can be an Option for Dominant Polycystic Kidney Disease: An Observational Study
| Autor: | Inés Castellano, Darío Janeiro, Rafael Selgas, Patricia Martínez-Miguel, Guadalupe Caparrós, Alberto Ortiz, Carmen Felipe, Tato A, José Portolés, Maite Rivera, María José Fernández-Reyes, Gloria del Peso, Mayra Ortega, Paula López-Sánchez, Vanessa Perez-Gómez |
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| Rok vydání: | 2015 |
| Předmět: |
kidney transplant
Adult Male medicine.medical_specialty abdominal wall complications medicine.medical_treatment Urology Peritonitis Comorbidity urologic and male genital diseases Kidney transplant Peritoneal dialysis Cohort Studies medicine Polycystic kidney disease Humans Prospective Studies Contraindication Aged urogenital system business.industry technique failure Original Articles General Medicine Peritoneal dialysis outcomes Middle Aged dialysis modality Polycystic Kidney Autosomal Dominant medicine.disease mortality Kidney Transplantation female genital diseases and pregnancy complications Survival Rate Treatment Outcome Nephrology Female Observational study business Peritoneal Dialysis |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 1718-4304 0896-8608 |
| DOI: | 10.3747/pdi.2014.00029 |
| Popis: | Background Autosomal dominant polycystic kidney disease (ADPKD) has been considered a relative contraindication for peritoneal dialysis (PD), although there are few specific studies available. Methods A multicenter historical prospective matched-cohort study was conducted to describe the outcome of ADPKD patients who have chosen PD. All ADPKD patients starting PD ( n = 106) between January 2003 and December 2010 and a control group (2 consecutive patients without ADPKD) were studied. Mortality, PD-technique failure, peritonitis, abdominal wall leaks and cyst infections were compared. Results Patients with ADPKD had similar age but less comorbidity at PD inclusion: Charlson comorbidity index (CCI) 4.3 (standard deviation [SD] 1.6) vs 5.3 (SD 2.5) p < 0.001, diabetes mellitus 5.7% vs 29.2%, p < 0.001 and previous cardiovascular events 10.4% vs 27.8%, p < 0.001. No differences were observed in clinical events that required transient transfer to hemodialysis, nor in peritoneal leakage episodes or delivered dialysis dose. The cyst infection rate was low (0.09 episodes per patient-year) and cyst infections were not associated to peritonitis episodes. Overall technique survival was similar in both groups. Permanent transfer to hemodialysis because of surgery or peritoneal leakage was more frequent in ADPKD. More ADPKD patients were included in the transplant waiting list (69.8 vs 58%, p = 0.04) but mean time to transplantation was similar (2.08 [1.69 – 2.47] years). The mortality rate was lower (2.5 vs 7.6 deaths/100 patient-year, p = 0.02) and the median patient survival was longer in ADPKD patients (6.04 [5.39 – 6.69] vs 5.57 [4.95 – 6.18] years, p = 0.024). Conclusion Peritoneal dialysis is a suitable renal replacement therapy option for ADPKD patients. |
| Databáze: | OpenAIRE |
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