Associations Between Objectively Measured Sleep and Cognition: Main Effects and Interactions With Race in Adults Aged ≥50 Years

Autor: Jocelynn T Owusu, Jill A Rabinowitz, Marian Tzuang, Yang An, Melissa Kitner-Triolo, Vadim Zipunnikov, Mark N Wu, Sarah K Wanigatunga, Jennifer A Schrack, Roland J Thorpe, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnick, Adam P Spira
Rok vydání: 2022
Předmět:
Zdroj: The Journals of Gerontology: Series A. 78:454-462
ISSN: 1758-535X
1079-5006
Popis: Background This study examined associations of actigraphy-estimated sleep parameters with concurrent and future cognitive performance in adults aged ≥ 50 years and explored interactions with race. Methods Participants were 435 cognitively normal adults in the Baltimore Longitudinal Study of Aging who completed wrist actigraphy at baseline (mean = 6.6 nights) and underwent longitudinal testing of memory, attention, executive function, language, and visuospatial ability. On average, participants with follow-up data were followed for 3.1 years. Primary predictors were baseline mean total sleep time, sleep onset latency, sleep efficiency (SE), and wake after sleep onset (WASO). Fully adjusted linear mixed-effects models included demographics, baseline health-related characteristics, smoking status, sleep medication use, APOE e4 carrier status, and interactions of each covariate with time. Results In adjusted models, higher SE (per 10%; B = 0.11, p = .012) and lower WASO (per 30 minutes; B = −0.12, p = .007) were associated with better memory cross-sectionally. In contrast, higher SE was associated with greater visuospatial ability decline longitudinally (B = −0.02, p = .004). Greater WASO was associated with poorer visuospatial ability cross-sectionally (B = −0.09, p = .019) but slower declines in visuospatial abilities longitudinally (B = 0.02, p = .002). Several sleep-cognition cross-sectional and longitudinal associations were stronger in, or limited to, Black participants (compared to White participants). Conclusions This study suggests cross-sectional sleep-cognition associations differ across distinct objective sleep parameters and cognitive domains. This study also provides preliminary evidence for racial differences across some sleep-cognition relationships. Unexpected directions of associations between baseline sleep and cognitive performance over time may be attributable to the significant proportion of participants without follow-up data and require further investigation.
Databáze: OpenAIRE
Externí odkaz: