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There are several definitions which are suggested to explain how metabolic syndrome is appeared. According to modern scientific information G. Reaven was one of the first who tried to explain the term of "syndrome X" or "metabolic syndrome" in 1988. He found out such symptoms as hyperinsulinemia, tissue-induced insulin resistance (IR), impaired glucose tolerance, high density of lipoprotein, hypertriglyceridemia that lowers cholesterol (HDL cholesterol) and arterial hypertension (AG) were cоmposition of metabolic syndrome. However, considering the metabolic syndrome it started from earlier times. In 1966 J. Camus revealed that Hyperlipidemia, 2nd ed mutual cause of type diabetes and gout diseases had аn interrelation. He called this type of metabolic disorder as "metabolic trisyndrome" (trisyndrome metabolique). In 1968, N. Mehnert and N. Kuhlmann explained that in hypertension and diabetes mellitus the factors and causes of metabolic disorders are related and discovered new syndrome "abundance syndrome". In 1988 M. Hanefeld and W. Leonard suggested to call different metabolic disorders similarities as " Metabolic syndrome ". After that in 1989 N.M. Kaplan described Metabolic syndrome concept as abdominal obesity and clinical metabolic disorders and lead the theories that destruction of impaired glucose tolerance, arterial hypertension, obesity and delayed dyslipidemia, called it a "deadly quartet". Consideration of The main pathogenetic mechanism of this syndrome, usually the term "insulin resistance syndrome" is also used as a synonym. |
