Electrographic spikes are common in wildtype mice
| Autor: | Stephen H.T. Lammers, Chloe E. Super, Hannah Purtell, Elizabeth Bainbridge, Sameer C. Dhamne, Meera E. Modi, Mustafa Sahin, Sarika Gurnani, Alexander Rotenberg, Mustafa Q. Hameed, Ervin L. Johnson |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Video Recording Action Potentials Mice Transgenic Electroencephalography Biology Article Mice 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Rhythm Normal EEG Seizures medicine Animals Telemetry Wakefulness medicine.diagnostic_test Wild type medicine.disease Sleep in non-human animals Mice Inbred C57BL 030104 developmental biology Neurology Eeg activity Neurology (clinical) Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy Behav |
| ISSN: | 1525-5050 |
| Popis: | High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent form of absence epilepsy or a normal feature of rodent sleep EEG. In contrast, little is known about epileptiform spikes in WT mice. We thus characterize and quantify epileptiform discharges in WT mice for the first time. Thirty-six male WT C57 mice with 24-h wireless telemetry video-EEG recordings were manually scored by blinded reviewers to mark individual spikes and spike trains. Epileptiform spikes were detected in 100% of the recorded WT mice, and spike trains of at least three spikes were recorded in 90% of mice. The spikes were more frequent during the day than at night and were inversely correlated to each animal's locomotor activity. However, the discharges were not absent during active nighttime periods. These discharges may indicate a baseline tendency toward epileptic seizures or perhaps are benign variants of normal rodent background EEG. Nevertheless, a better understanding of baseline WT EEG activity will aid in differentiating pathological and normal EEG activity in mouse epilepsy models. |
| Databáze: | OpenAIRE |
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