Effects of estrogen and progestin on the CO2 sensitivity of hemispheric cerebral blood volume
| Autor: | Tamás Mersich, Szabolcs Várbíró, Emese Szelke, Katalin Komjáti, Péter Sándor, Béla Székács |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Ovariectomy Rats Sprague-Dawley Sex hormone-binding globulin Internal medicine Animals Medicine Cerebrum Blood Volume biology business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Estrogens Carbon Dioxide Co2 sensitivity Rats Postmenopause Disease Models Animal Cerebral blood volume Endocrinology Estrogen Cerebrovascular Circulation Circulatory system biology.protein Ovariectomized rat Female Blood Gas Analysis Progestins business Progestin Hormone |
| Zdroj: | Menopause. 15:346-351 |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/gme.0b013e31813c688d |
| Popis: | Objective: High CO 2 sensitivity is one of the major characteristics of the cerebrovascular bed. It has been shown to be influenced by many differrent factors (eg, sex hormones). Design: The effect of ovariectomy and subsequent female sexual hormone treatment on the steady-state hemispheric cerebral blood volume and CO 2 responsiveness of the hemispheric blood vessels was studied on anesthetized, ventilated, normotensive, normoxic rats. Cerebral blood volume was measured with Tomita's photoelectric method with Sandor's modification. Results: Steady-state cerebral blood volume values in ovariectomized rats did not differ from those found in control animals. The CO 2 responsiveness of hemispheric blood vessels was higher in ovariectomized and progestin-treated, but not estrogen-treated, animals compared with controls. Conclusions: Our results demonstrate that the CO 2 sensitivity of the hemispheric vessels is sex hormone dependent. Estrogen and progestin treatment have opposite effects on this cerebral circulatory parameter. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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