Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study

Autor: Mansour Hosseini, Hamidreza Moussavi, Hadi Karimzadeh, Mohammadreza Shakibi, Mohammad Ali Nazarinia, Farhad Gharibdoost, Amirhossein Salari, Mansour Karimifar, Faegheh Ebrahimi Chaharom, Zahra Mirfeizi, Karim Mowla, Nassim Anjidani, Mansour Salesi, Maryam Sahebari, Peyman Mottaghi, Ahmadreza Jamshidi
Rok vydání: 2021
Předmět:
Zdroj: Advances in Therapy. 38:1290-1300
ISSN: 1865-8652
0741-238X
Popis: Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA). In this open-label, multicenter, prospective, observational, post-marketing surveillance study, 583 patients received biosimilar etanercept 25 mg twice weekly or 50 mg once weekly and were followed up to 12 months. The primary objective was to evaluate the safety of biosimilar etanercept by documenting all the adverse events in the case report forms throughout the study period. The secondary objective was to evaluate the effectiveness of biosimilar etanercept in study patients, where longitudinal changes in health assessment questionnaire (HAQ), pain, and disease activity scores were assessed. A total of 583 patients (44.80 ± 13.09 years of age) were included and followed for an average of 8.12 ± 3.96 months. Among all patients, 172 (29.50%) experienced at least one adverse event, and injection site reaction, abdominal pain, and upper respiratory tract infection were the most common. HAQ scores decreased from 1.32 ± 0.77 at baseline to 0.81 ± 0.61 at 12 months in patients with RA/PsA (p
Databáze: OpenAIRE
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