Combination of Forced Diuresis with Additional Late Imaging in 68Ga-PSMA-11 PET/CT: Effects on Lesion Visibility and Radiotracer Uptake
| Autor: | Alberts, Ian, Huenermund, Jan Niklas, Sachpekidis, Christos, Zacho, Helle Damgaard, Mingels, Clemens, Dijkstra, Lotte, Bohn, Karl Peter, Laeppchen, Tilman, Gourni, Eleni, Rominger, Axel, Afshar-Oromieh, Ali |
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| Rok vydání: | 2021 |
| Předmět: |
Diuresis
030218 nuclear medicine & medical imaging dual-time point Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine PSMA medicine Radiology Nuclear Medicine and imaging furosemide PET-CT Urinary bladder business.industry Furosemide Retrospective cohort study medicine.disease diuresis medicine.anatomical_structure 030220 oncology & carcinogenesis Renal physiology medicine.symptom Nuclear medicine business hydration medicine.drug |
| Zdroj: | Alberts, I, Huenermund, J N, Sachpekidis, C, Zacho, H D, Mingels, C, Dijkstra, L, Bohn, K P, Laeppchen, T, Gourni, E, Rominger, A, Rominger, A & Afshar-Oromieh, A 2021, ' Combination of forced diuresis with additional late imaging in 68 Ga-PSMA-11 PET/CT : Effects on lesion visibility and radiotracer uptake ', Journal of Nuclear Medicine, vol. 62, no. 9, pp. 1252-1257 . https://doi.org/10.2967/jnumed.120.257741 |
| ISSN: | 2159-662X 0161-5505 |
| Popis: | Purpose: Renal excretion of some prostate specific membrane antigen (PSMA)-ligands and consequently increased bladder activity can obscure locally relapsing prostate cancer (PC) lesions in PSMA-PET/CT. Furthermore, additional late imaging in PSMA-PET/CT provides a useful method to clarify uncertain findings. The aim of this retrospective study was to investigate a modified imaging protocol combining late additional imaging with hydration and forced diuresis in individuals undergoing additional late scanning for uncertain lesions or low PSA. Methods: We compared two protocols: one group of patients undergoing 68Ga-PSMA-11-PET/CT were examined at 90 min p.i. with 1L oral hydration beginning at 30min p.i. and 20mg of Furosemide i.v. at 1h p.i. followed by additional late imaging at 2.5h p.i. without further preparation ("old" protocol). A second group received the same procedure as before, with an additional 0.5L oral hydration and 10mg of Furosemide i.v. 30min before the late imaging. 132 patients (76 "old" protocol, 56 "new" protocol) were examined with respect to urinary bladder activity (SUVmean), PC-lesion uptake (SUVmax) and lesion contrast (tumor-SUVmax÷bladder-SUVmean for local relapses and tumor-SUVmax÷gluteal-musculature-SUVmean for non-local PC lesions). Results: Bladder activity was significantly greater for the "old" protocol in the late scans compared to the "new" protocol (ratio of bladder activity (2.5h÷1.5h): 2.33±1.17 vs. 1.37±0.50, p |
| Databáze: | OpenAIRE |
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