Association of Asymmetric Dimethylarginine With Acute Pancreatitis-Induced Hyperglycemia
| Autor: | Vesna Kovacic Vicic, Ante Bogut, Marijana Vučić Lovrenčić, Ivan Zaja, Ivana Meter, Gorana Trgo, Maja Radman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Time Factors Endocrinology Diabetes and Metabolism Gastroenterology Severity of Illness Index Impaired glucose tolerance chemistry.chemical_compound 0302 clinical medicine Endocrinology Prospective Studies Aged 80 and over Glucose tolerance test acute pancreatitis asymmetric dimethylarginine reactive oxygen species reactive nitrogen species diabetes mellitus medicine.diagnostic_test Nitrotyrosine Middle Aged Fructosamine 8-Hydroxy-2'-Deoxyguanosine Acute Disease Acute pancreatitis 030211 gastroenterology & hepatology Adult medicine.medical_specialty Ringer's Lactate Enzyme-Linked Immunosorbent Assay Arginine 03 medical and health sciences Internal medicine Diabetes mellitus Internal Medicine medicine Humans Glycemic Aged Hepatology business.industry Deoxyguanosine Glucose Tolerance Test medicine.disease 030104 developmental biology chemistry Pancreatitis Hyperglycemia Fluid Therapy Tyrosine Isotonic Solutions Asymmetric dimethylarginine business Biomarkers |
| DOI: | 10.1097/mpa.0000000000000516 |
| Popis: | Objective The objective of this study was to investigate the relationship between asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, oxidative-nitrosative damage, and glucoregulation in acute pancreatitis (AP). Methods The study evaluated serum levels of ADMA, nitrotyrosine, and urinary 8-hydroxydeoxyguanosine in 40 male patients hospitalized for AP at baseline and at 2 and 10 days of treatment, respectively. The patients were classified into a mild and a moderately severe AP group (MAP and MSAP, respectively) according to Atlanta classification criteria. Glycemic status was evaluated by a 75-g oral glucose tolerance test 1 month after AP onset. Forty age-matched healthy subjects served as control subjects. Results Significant decrease of ADMA and increased levels of nitrotyrosine and urinary 8-hydroxydeoxyguanosine were found in MSAP, but not in MAP at baseline, with ADMA correction toward control levels at the 10th day of treatment. Fructosamine was found to significantly influence ADMA levels (r = -0.362, P = 0.002). After AP recovery, either impaired glucose tolerance or diabetes was identified with the oral glucose tolerance test in 10.5% and 92.8% of patients with MAP and MSAP, respectively. Conclusions Insufficient inhibition of nitric oxide synthesis, through reduced bioavailability of ADMA, might be a novel significant contributory factor to the severity of AP and subsequent development of hyperglycemia. |
| Databáze: | OpenAIRE |
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