AB291. SPR-18 Correlation of sacral nerve lead targeting and urological efficacy: motor mapping, electrode position, and stimulation amplitude
| Autor: | Thaddeus S. Brink, Janine Wotton, Adam Steiner, Xin Su, Nicki Reinking, Dwight E. Nelson, Lance Zirpel |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
sheep
business.industry Neuromodulation Urology 030232 urology & nephrology Stimulation motor mapping Anatomy Neuromodulation (medicine) 03 medical and health sciences 0302 clinical medicine Amplitude Reproductive Medicine Electrode Sacral nerve Medicine Motor mapping Lead (electronics) business bladder lead targeting 030217 neurology & neurosurgery Abstract Biomedical engineering |
| Zdroj: | Translational Andrology and Urology |
| ISSN: | 2223-4691 |
| Popis: | Objective Sacral neuromodulation (SNM) is a clinically used therapy for refractory urge frequency and incontinent patients. Using a recently developed sheep model, this preclinical study retrospectively evaluated the relationship between implanted sacral lead locations, motor threshold (MT) values, motor mapping, and acute urological efficacy to determine if acute location and physiological measurements are correlated. Methods Twelve female polypay sheep were implanted with bilateral InterStim® devices (Model 3058) connected to quadripolar leads (model 3889) placed in the S2-4 foramina with S3 as the ideal target. CT scans at post-op and ≥12 months later were used for 3D rendering using MedCAD points placed on the sacrum and lead contacts to compare coordinates across animals. Acute cystometry was performed to test responses to SNM (0.21 ms PW, 10 Hz) at maximum tolerable amplitude (MTA). MT values were obtained by visual identification of the first motor response and the motor reflex was mapped to an anatomical map. Results Sheep were categorized as responders (n=6; 50%) or non-responders (n=6; 50%) based on ≥50% increase in bladder capacity to acute SNM. There was a significant difference in motor mapping areas between responders (peri-anal contacts) and non-responders (activation of leg) (chi-square; P |
| Databáze: | OpenAIRE |
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