Effects of fluoroquinolones on HERG currents
| Autor: | Christine Schmidt, Olaf Pongs, Rainer Netzer, Ulrike Bischoff |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities ERG1 Potassium Channel Patch-Clamp Techniques Potassium Channels hERG CHO Cells Pharmacology Anti-Infective Agents Transcriptional Regulator ERG Cricetinae medicine Animals Humans cardiovascular diseases Patch clamp Cation Transport Proteins Antibacterial agent biology Dose-Response Relationship Drug Chemistry Chinese hamster ovary cell Grepafloxacin In vitro Ether-A-Go-Go Potassium Channels DNA-Binding Proteins Sparfloxacin Mechanism of action Potassium Channels Voltage-Gated biology.protein Trans-Activators medicine.symptom medicine.drug Fluoroquinolones |
| Zdroj: | European journal of pharmacology. 406(3) |
| ISSN: | 0014-2999 |
| Popis: | We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath application of sparfloxacin, moxifloxacin and grepafloxacin produced an inhibition of HERG outward currents at -40 mV with EC(50) of 13.5+/-0.8, 41. 2+/-2.0 and 37.5+/-3.3 microg/ml, respectively. Current inhibitions were reversible after washout of the compounds. By contrast, ciprofloxacin at concentrations of up to 100 microg/ml did not effect HERG outward currents. |
| Databáze: | OpenAIRE |
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