Hypoxia-inducible factor-1α cooperates with histone Lys methylation to predict prognosis in esophageal squamous cell carcinoma
| Autor: | Yiping Li, Xiaohui Shen, Ying Xu, Menghan Zhou, Rong Yin, Min Liu, Hong Fan, Shaofeng Lin, Qin Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Esophageal Neoplasms Clinical Biochemistry Methylation Histone H4 Histones 03 medical and health sciences Histone H3 0302 clinical medicine Drug Discovery Histone methylation Biomarkers Tumor Medicine Humans Epigenetics Aged biology business.industry Biochemistry (medical) Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit Prognosis digestive system diseases Survival Rate 030104 developmental biology Histone Hypoxia-inducible factors 030220 oncology & carcinogenesis biology.protein Cancer research H3K4me3 lipids (amino acids peptides and proteins) Female Esophageal Squamous Cell Carcinoma business |
| Zdroj: | Biomarkers in medicine. 15(7) |
| ISSN: | 1752-0371 |
| Popis: | Aim: To investigate hypoxia-inducible factor-1α (HIF-1α) and histone methylation markers as potential indicators of prognosis in esophageal squamous cell carcinoma (ESCC). Patients & methods: The prognostic value of HIF-1α and histone methylation markers levels was analyzed using Kaplan–Meier survival analysis. Results: HIF-1α protein expression was higher in ESCC tumors than in paracancerous tissues. Histone H3 Lys9 trimethylation (H3K9me3), histone H3 Lys27 trimethylation (H3K27me3), histone H3 Lys4 trimethylation (H3K4me3) and histone H4 Lys20 trimethylation (H4K20me3) were significantly upregulated in ESCC tissues. HIF-1α was only positively correlated with H3K9me3 and H3K4me3 expression. Kaplan–Meier analysis indicated that H3K9me3, H3K27me3, H4K20me3 and histone H3 Lys36 trimethylation (H3K36me3) were independent indicators of prognosis for ESCC. Conclusion: This study identified a pattern of epigenetic methylation markers and HIF-1α expression in ESCC, and their combined evaluation might improve survival prediction for ESCC patients. |
| Databáze: | OpenAIRE |
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