| Popis: |
Nonalcoholic steatohepatitis (NASH) characterizes with massive lipid deposition in hepatocytes and it's often associated with hepatic inflammation and other severe metabolism syndromes. The intervention of NASH can prevent its further progression into hepatocarcinoma. Here, we have successfully constructed a liver-targeted Ce-based hollowed mesoporous nanocarries loaded with a bioactive drugs may offer a satisfactory and effective approach for eliminating NASH. The liver section precise targeting was realized by covalently linked galactose (Gal), which can specifically recognized by receptors in the membrane of hepatocytes. Meanwhile, NASH treated drugs, resveratrol (Res) molecules were efficiently loaded in the pores and cavity of CeO2 (Res@H-CeO2-Gal). In steatotic HepG2 cells (free fatty acid induction), the nanosystem enhanced the cellular Res internalization for improvement of anti-lipogenesis capability. In NASH mice, Res@H-CeO2-Gal increased Res delivery to liver sections for the reduction of lipid accumulation and enhanced anti-inflammation ability from the antioxidant ability of Ce based nanocarries that effectively recovered NASH mice into normal state. This finding proved that the hepatic targeting and Res delivery nanoplatform could potentially act as a biosafety and promising strategy for elimination of NASH and other liver diseases. |
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