Aortic Calcium Uptake and Efflux in Spontaneously Hypertensive and Inbred Dahl Rats
| Autor: | John P. Rapp, Michael O. Onwochei, Cuong X. Nghiem |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Physiology Drug Resistance Biological Transport Active Aorta Thoracic Locus (genetics) In Vitro Techniques Sodium Chloride Ion Channels Rats Mutant Strains Species Specificity Rats Inbred SHR Internal medicine Genotype Internal Medicine Animals Medicine Allele business.industry Unilateral nephrectomy Calcium uptake Rats Blood pressure Endocrinology Hypertension Calcium Female Efflux Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Hypertension. 4:493-499 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-198608000-00016 |
| Popis: | Calcium uptake and efflux were studied in aortic tissues of three inbred rat strains; spontaneously hypertensive rats (SHR), inbred Dahl salt-sensitive rats (S/JR) and inbred Dahl salt-resistant (R/JR) rats. Previously, we showed that a single genetic locus (Hyp-2 locus) controls vascular smooth muscle responses to ionic cobalt (Co2+) among these three strains. Spontaneously hypertensive rats carry an allele at the Hyp-2 locus mediating high blood pressure, but S/JR and R/JR both carry an allele at this locus for low blood pressure. In the present work, resting Ca2+ uptake in aortic tissue was found to be increased in SHR and S/JR relative to R/JR. It was concluded that resting aortic Ca2+ uptake and genotypes at the Hyp-2 locus are not concordant among strains and that the increased Ca2+ uptake of the hypertensive strains must, therefore, be mediated by a mechanism other than the Hyp-2 locus. Resting aortic Ca2+ uptake was shown also to be increased in hypertension-resistant R/JR rats by the extreme treatment of unilateral nephrectomy plus 8% NaCl diet which induces hypertension in R/JR rats. The high resting vascular smooth muscle calcium-uptake seen in the hypertensive strains is, therefore, not a unique primary genetic cause of hypertension since it can also be induced by environmental manipulation. High resting aortic Ca2+ uptake is either a consequence of hypertension or a final common physiological pathway by which genetic and environmental factors influence blood pressure. |
| Databáze: | OpenAIRE |
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