Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension

Autor: Blazenka Dobrosevic, Tajana Turk, Tihana Šimundić, Boris Takac, Jerko Barbić, Bojan Jelaković, Andrea Dzumhur, Ines Sahinovic
Rok vydání: 2017
Předmět:
Arterial hypertension
0301 basic medicine
Adaptive immunity
Innate immunity
Interleukin 17A
Toll-like receptor 4
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Adrenergic beta-Antagonists
030204 cardiovascular system & hematology
lcsh:RC870-923
Monocytes
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
lcsh:Dermatology
medicine
Humans
Diuretics
Receptor
Antihypertensive Agents
business.industry
Monocyte
Interleukin-17
Immunity
Case-control study
Interleukin
Arteries
General Medicine
lcsh:RL1-803
lcsh:Diseases of the genitourinary system. Urology
Cross-Sectional Studies
030104 developmental biology
medicine.anatomical_structure
Blood pressure
Endocrinology
lcsh:RC666-701
Nephrology
Case-Control Studies
Hypertension
TLR4
Interleukin 17
Cardiology and Cardiovascular Medicine
business
Zdroj: Kidney & Blood Pressure Research, Vol 42, Iss 1, Pp 99-108 (2017)
ISSN: 1423-0143
1420-4096
DOI: 10.1159/000471900
Popis: Background/Aims: Immune responses are involved in arterial hypertension. An observational cross-sectional case control study was conducted to estimate the association between Toll-like receptor 4 (TLR4) expression and interleukin (IL)-17A serum levels in patients with controlled and non-controlled hypertension. Methods: We have enrolled 105 non-complicated otherwise healthy hypertensive patients: 53 with well-controlled blood pressure and 52 non-controlled. TLR4 peripheral monocytes expression and serum IL-17A levels were determined by flow cytometry and ELISA, respectively. Results: Non-controlled patients exhibited higher TLR4 expression than well-controlled (25.60 vs. 21.99, P=0.011). TLR4 expression was lower in well-controlled patients who were prescribed beta blockers (18.9 vs. 22.6, P=0.005) and IL-17A concentration was higher in patients using diuretics in either group (1.41 vs. 2.01 pg/ml, PP= 0.023; non-controlled 1.6 vs. 2.3 pg/ml, P=0.001). Correlation between IL-17A concentration and hypertension duration was observed in non-controlled patients (Spearman correlation coefficient . ρ=0.566, PP=0.020). Conclusions: Arterial hypertension stimulates the immune response regardless of blood pressure regulation status. Prolonged hypertension influences peripheral monocyte TLR4 expression and IL-17A serum levels. Anti-hypertensive drugs have different immunomodulatory effects: diuretics are associated with higher IL-17A concentration and beta-blockers with lower TLR4 expression.
Databáze: OpenAIRE
Externí odkaz: