Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp
| Autor: | Jongki Hong, Dong Soon Im, Ju Hee Park, Hae Young Chung, Jae Sue Choi, Eun La Kim, Jee H. Jung, Haibo Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Jellyfish
Scyphozoa Stereochemistry Clinical Biochemistry Pharmaceutical Science Fungus Biochemistry chemistry.chemical_compound biology.animal Drug Discovery Animals Cytochalasin Cytotoxicity Molecular Biology Molecular Structure biology Organic Chemistry Fungi Absolute configuration Stereoisomerism biology.organism_classification Cytochalasins chemistry Cell culture Phoma Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:2096-2099 |
| ISSN: | 0960-894X |
| Popis: | Four new cytochalasin derivatives ( 1 – 4 ), together with proxiphomin ( 5 ), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher’s method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116). |
| Databáze: | OpenAIRE |
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