Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle
| Autor: | Randall Toy, Ketan B. Ghaghada, Jenna Pansky, Aaron T. Mayer, Emily Tran, Lisa Bauer, Morgan Tam, Dishen Lin, William P. Schiemann, Peter Vicente, Samantha Tucci, Aaron Abramowski, Mark A. Griswold, Elizabeth Doolittle, Efstathios Karathanasis, Pubudu M. Peiris |
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| Rok vydání: | 2013 |
| Předmět: |
Drug
media_common.quotation_subject Pharmaceutical Science Nanoparticle Antineoplastic Agents Breast Neoplasms Mice Drug Delivery Systems Cell Line Tumor medicine Distribution (pharmacology) Effective treatment Animals Humans Breast media_common Mice Inbred BALB C business.industry Micrometastasis Low dose Cancer medicine.disease Neoplasm Micrometastasis Immunology Cancer cell Cancer research Nanoparticles Female business |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 173 |
| ISSN: | 1873-4995 |
| Popis: | While potent cytotoxic agents are available to oncologists, the clinical utility of these agents is limited due to their non-specific distribution in the body and toxicity to normal tissues leading to use of suboptimal doses for eradication of metastatic disease. Furthermore, treatment of micrometastases is impeded by several biobarriers, including their small size and high dispersion to organs, making them nearly inaccessible to drugs. To circumvent these limitations in treating metastatic disease, we developed a multicomponent, flexible chain-like nanoparticle (termed nanochain) that possesses a unique ability to gain access to and be deposited at micrometastatic sites. Moreover, coupling nanochain particles to radiofrequency (RF)-triggered cargo delivery facilitated widespread delivery of drug into hard-to-reach cancer cells. Collectively, these features synergistically facilitate effective treatment and ultimately eradication of micrometastatic disease using a low dose of a cytotoxic drug. |
| Databáze: | OpenAIRE |
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