Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
| Autor: | Jana Karbanová, Chloe Bolton, Donald Singer, Ralf H. Adams, Stefano Ardu, Mengyuan Zhao, Yuxing Bai, Jemma Victoria Walker, Wai Ling Kok, Kishor K. Sivaraj, Qingguo Lai, Yan Gao, Moustapha Kassem, Heng Zhuang, Yuying Liu, Kai Yang, Portia Rebecca Clare Grayson, Christopher Tredwin, Basem M. Abdallah, Jihui Liu, Alexander C. Zambon, Shuo Chen, Bing Hu, Tim Lee, Denis Corbeil, Shuang Wang, Charlotte Sara Illsley |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Epigenomics Cellular differentiation General Physics and Astronomy Priming (immunology) Gene Expression 02 engineering and technology Stem cells Mice Homeostasis Stem Cell Niche lcsh:Science Mice Knockout education.field_of_study Multidisciplinary Cell Differentiation 021001 nanoscience & nanotechnology Cell biology Incisor DLK1 Models Animal Female Stem cell 0210 nano-technology Signal Transduction Science Population Notch signaling pathway Stem-cell differentiation Biology Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences stomatognathic system Animals Humans Cell Lineage Rats Wistar education Wound Healing Mesenchymal stem cell Calcium-Binding Proteins Mesenchymal Stem Cells General Chemistry Rats stomatognathic diseases 030104 developmental biology Dentin Molar Third lcsh:Q Wound healing Stem-cell niche |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019) Walker, J V, Zhuang, H, Singer, D, Illsley, C S, Kok, W L, Sivaraj, K K, Gao, Y, Bolton, C, Liu, Y, Zhao, M, Grayson, P R C, Wang, S, Karbanová, J, Lee, T, Ardu, S, Lai, Q, Liu, J, Kassem, M, Chen, S, Yang, K, Bai, Y, Tredwin, C, Zambon, A C, Corbeil, D, Adams, R, Abdallah, B M & Hu, B 2019, ' Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation ', Nature Communications, vol. 10, no. 1, 3596 . https://doi.org/10.1038/s41467-019-11611-0 Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With Notch signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation. Dlk1’s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration. Mouse incisor growth depends upon mesenchymal stromal cells (MSCs) and transit amplifying cells (TACs). Here the authors describe a distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts. |
| Databáze: | OpenAIRE |
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