Monitoring for HHV-6 infection after renal transplantation:: evaluation of risk factors for sustained viral replication
| Autor: | Clarisse Martins Machado, Luis Fernando Aranha Camargo, Silvia C.C. Christ, Camille N. Kotton, Claudia R. Luiz, José Osmar Medina Pestana, Cynthia L.M. Canto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent HHV-6 Infection viruses Herpesvirus 6 Human Virus Replication Gastroenterology Asymptomatic Living donor Polymerase Chain Reaction law.invention law Risk Factors Internal medicine medicine Humans Prospective Studies Renal Insufficiency Time to onset Polymerase chain reaction Aged Transplantation REPLICAÇÃO VIRAL business.industry Graft Survival Herpesviridae Infections Middle Aged Virology Kidney Transplantation surgical procedures operative Treatment Outcome Viral replication DNA Viral Female medicine.symptom business Viral load |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | BACKGROUND Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear. METHODS Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 replication between February 2007 and February 2008. Plasma samples for DNA detection were collected from the donor and the recipient before transplantation and from the recipient weekly for the first 2 months after transplantation and then every 2 weeks for 2 additional months. HHV-6 active infection was defined as detection of viral DNA in plasma, by polymerase chain reaction, in at least two consecutive samples over an interval of at least 1 week. RESULTS Active viral infection was detected in 25% of the recipients before transplantation and 27% (8 of 30) of the patients after transplantation. The mean time to onset of viral replication was 28.1 days after transplantation and 7 of 8 (87.5%) were asymptomatic. Risk factors associated with active HHV-6 infection were receiving an organ from a living donor (P=0.028), recipients with IgM antibodies detected before transplantation (P=0.005), and pretransplantation recipient HHV-6 viral load more than 10,000 copies/mL plasma (P=0.034). CONCLUSIONS Active HHV-6 infection occurs early after renal transplantation and is mostly asymptomatic. Donor or recipient infection may occur at the time of transplantation and are related to higher rates of posttransplantation infections. |
| Databáze: | OpenAIRE |
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