Mapping intracellular pH in tumors using amide and guanidyl CEST-MRI at 9.4 T

Autor:	Philip S. Boyd, Johannes Breitling, Andreas Korzowski, Moritz Zaiss, Vanessa L. Franke, Karin Mueller‐Decker, Andrey Glinka, Mark E. Ladd, Peter Bachert, Steffen Goerke
Rok vydání:	2021
Předmět:	Mice Swine Animals Brain Radiology Nuclear Medicine and imaging Hydrogen-Ion Concentration Glioblastoma Amides Magnetic Resonance Imaging
Zdroj:	Magnetic resonance in medicineREFERENCES. 87(5)
ISSN:	1522-2594
Popis:	In principle, non-invasive mapping of the intracellular pH (pHCompensation of the concomitant effects was achieved by a ratiometric approach (i.e. the ratio of one CEST signal at different BIn porcine brain lysates, measurement of pH was feasible over a broad range of physiologically relevant pH values of 6.2 to 8.0, while being independent of changes in concentration. A median pHThe presented method enables non-invasive mapping of absolute pH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a83aa3e021a43691f6a60b81a4ad56f https://pubmed.ncbi.nlm.nih.gov/34958684 Zobrazit plný text záznamu Plný text