Influence of radiotherapy on intestinal microflora in cancer patients
| Autor: | Laura Cuzzolin, Marta Donini, D. Zambreri, C. Griso, Giuseppina Benoni |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
0301 basic medicine
Clostridium perfringens medicine.medical_treatment 030106 microbiology Uterine Cervical Neoplasms Enterotoxin medicine.disease_cause Microbiology Clostridia 03 medical and health sciences Enterotoxins Feces 0302 clinical medicine Clostridium medicine Humans Pharmacology (medical) Aged Pharmacology biology Clostridioides difficile Radiotherapy Dosage Clostridium difficile Middle Aged biology.organism_classification Endometrial Neoplasms Radiation therapy Intestines Infectious Diseases Oncology 030220 oncology & carcinogenesis Female Bacteriotherapy Enterococcus faecium |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1120-009X |
| Popis: | We investigated in 15 patients with carcinoma of the uterine cervix or endometrium, who were undergoing postoperative radiation therapy, the effects of different fractionated radiation exposures on counts of fecal bacteria, on the growth of Clostridium difficile and Clostridium perfringens enterotoxin production. We observed a generally significant decrease in intestinal microflora after the first radiation exposure, whereas at the end of radiotherapy all bacteria increased and reached basal values except Enterococcus faecium 1, lactobacilli and total anaerobes. In some patients we observed an overgrowth of some Clostridium spp. which were potential pathogens associated with clinical symptoms. We did not observe an influence of multiple radiations on C. perfringens enterotoxin fecal contents. We conclude that patients receiving radiotherapy may benefit from the intake of oral bacteriotherapy, i.e. live beneficial bacteria such as Bacillus subtilis at the beginning of the irradiation exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|