RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia
| Autor: | María del Puerto Morales, Luis Lezama, Maite Eceiza, Maialen Sagartzazu-Aizpurua, Maite Insausti, Izaskun Gil de Muro, Raluca M. Fratila, Rocío Costa, Eneko Garaio, Jesús M. de la Fuente, Oihane K. Arriortua, Jesus M. Aizpurua |
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| Přispěvatelé: | Eusko Jaurlaritza, Ministerio de Economía, Industria y Competitividad (España), Diputación General de Aragón, Ministerio de Economía y Competitividad (España), European Commission |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Thermogravimetric analysis
Materials science Biocompatibility Infrared spectroscopy Nanoparticle Citotoxicity Peptide 02 engineering and technology 010402 general chemistry 01 natural sciences Magnetite Colloid and Surface Chemistry Hyperthermia Physical and Theoretical Chemistry chemistry.chemical_classification RGD EMR Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology equipment and supplies 0104 chemical sciences Magnetic hyperthermia Chemical engineering chemistry Transmission electron microscopy Magnetic nanoparticles 0210 nano-technology human activities Biotechnology |
| Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname Digital.CSIC. Repositorio Institucional del CSIC |
| Popis: | To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target αvβ3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles. This work was supported by institutional funding from the Ministry of Economy Industry and Competitiveness and Basque Government under Projects MAT2016-78266-P, FEDER, GIC-IT-570-13, Fondo Social de la DGA (grupos DGA), SAF2014-54763-C2-2-R. Technical and human support provided by SGIker (UPV/EHU) is also gratefully acknowledged. A grant from Gobierno Vasco to M.S.-A. (POS_2015_2-0048) is acknowledged. |
| Databáze: | OpenAIRE |
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