Molecules involved in T–B co-stimulation and B cell homeostasis: possible targets for an immunological intervention in autoimmunity
| Autor: | Klaus Warnatz, Hans H. Peter |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cell signaling
Recombinant Fusion Proteins T-Lymphocytes Clinical Biochemistry Cell Communication Biology medicine.disease_cause Receptors Tumor Necrosis Factor Autoimmune Diseases Immunological synapse Autoimmunity Immune system CD28 Antigens Co-stimulation B cell homeostasis Drug Discovery medicine Animals Humans B-cell activating factor B cell Pharmacology B-Lymphocytes Antibodies Monoclonal Cell Differentiation Common Variable Immunodeficiency medicine.anatomical_structure Tumor Necrosis Factors Immunology B7-1 Antigen Tumor Necrosis Factor Inhibitors Signal Transduction |
| Zdroj: | Expert Opinion on Biological Therapy. 5:S61-S71 |
| ISSN: | 1744-7682 1471-2598 |
| DOI: | 10.1517/14712598.5.1.s61 |
| Popis: | The deepened knowledge of co-stimulatory mechanisms within the immunological synapse and the emerging biological principles governing B cell homeostasis provide a plethora of new possibilities to selectively block or enhance immune responses. These mechanisms are highly relevant to the development of new treatment modalities for autoimmune diseases. Here we review approaches to antagonise members of the CD28-B7 superfamily as well as the TNF receptor ligand superfamily members, BAFF and APRIL, and their corresponding receptors on B cells (BAFF-R, TACI and BCMA). The proof of principle that such manipulations have indeed profound consequences for the human immune response comes from genetically manipulated mouse models, and, more importantly, from human immunodeficiency syndromes. Thus, the recent discovery of deletions in the ICOS, BAFF-R and TACI genes leading to disturbances in late B cell differentiation and hypogammaglobulinaemia underline the potential impact of targeting these molecules for therapeutic strategies in autoimmune disorders. |
| Databáze: | OpenAIRE |
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