Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma
| Autor: | Albert Marcus Morrishow, J. K. Khandelwal, Jack Peter Green, Lindsay B. Hough |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pharmacology
medicine.medical_specialty Creatinine Chromatography Methylhistamines Metabolite Immunology Urine Toxicology Tele-methylhistamine Gas Chromatography-Mass Spectrometry Body Fluids chemistry.chemical_compound Endocrinology Cerebrospinal fluid chemistry Internal medicine medicine Humans Pharmacology (medical) Gas chromatography–mass spectrometry Receptor Histamine |
| Zdroj: | Agents and Actions. 12:583-590 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01965064 |
| Popis: | A gas chromatographic-mass spectrometric method described by us to measure tele-methylhistamine (t-MH) in brain was used to measure t-MH in human cerebrospinal fluid (CSF), urine and plasma. The presence of t-MH in these body fluids was rigorously established. No pros-methyl-histamine could be detected, and it was used as internal standard to quantify t-MH in the fluids. The mean levels of t-MH were: urine, 943 pmol/mg creatinine; plasma, 12.3 pmol/ml; and CSF, 2.2 pmol/ml. Parallel measurements of histamine by a radioenzymatic method showed, respectively, 182 pmol/mg creatinine; 19.5 pmol/ml; and 388 pmol/ml. The levels of HA in CSF, much higher than those of its metabolite, t-MH, are high enough to stimulate HA receptors in the central nervous system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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