Multiple gonococcal pilin antigenic variants are produced during experimental human infections
| Autor: | Ann E. Jerse, Myron S. Cohen, C. J. Wright, H. S. Seifert, J G Cannon |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Molecular Sequence Data Population medicine.disease_cause Genetic recombination Pilus Fimbriae Proteins Microbiology Gonorrhea Antigen medicine Antigenic variation Humans Amino Acid Sequence education Recombination Genetic Genetics education.field_of_study Base Sequence biology General Medicine biochemical phenomena metabolism and nutrition Neisseria gonorrhoeae Fimbriae Bacterial Pilin biology.protein bacteria Research Article Bacterial Outer Membrane Proteins |
| Zdroj: | Journal of Clinical Investigation. 93:2744-2749 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci117290 |
| Popis: | Gonococcal pilin variation is thought to allow immune evasion and change the adherence properties of the pilus. We have examined the process of pilin antigenic variation in human volunteers inoculated with strain FA1090. Our data show that pilin variation occurred throughout the process of infection, that at each time sampled after inoculation multiple pilin variants were present, and that later pilin variants appear to be recombinants between previously expressed genes and the silent storage pilin copies. Thus, during infection a large repertoire of proteins are available to the population to help avoid immune responses, to provide pili with varying functions, and to transmit to a new host. |
| Databáze: | OpenAIRE |
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