Meta-Analysis of Catheter Ablation versus Medical Therapy in Patients with Atrial Fibrillation Without Heart Failure
| Autor: | Arshad Adeel, Samsoor Zarak Muhammad, Khan Safi U, Alkhouli Mohamad, Khan Muhammad U, Zia Khan Muhammad, Shahzeb Khan Muhammad, Kaluski Edo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry medicine.medical_treatment Atrial fibrillation Catheter ablation 030204 cardiovascular system & hematology medicine.disease Cardioversion 03 medical and health sciences 0302 clinical medicine Internal medicine Heart failure medicine Cardiology 030212 general & internal medicine Tamponade Cardiology and Cardiovascular Medicine Pulmonary vein stenosis business Stroke Original Research |
| Zdroj: | J Atr Fibrillation |
| Popis: | INTRODUCTION: Catheter ablation has shown to reduce mortality in patient with atrial fibrillation (AF) and heart failure (HF) with reduced ejection fraction. Its effect on mortality in patients without HF has not been well elucidated. METHODS: Thirteen randomized controlled trials encompassing 3856 patients were selected using PubMed, Embase and the CENTRAL till April 2019. Estimates were reported as random effects risk ratio (RR) with 95% confidence intervals (CI). RESULTS: Compared with medical therapy, catheter ablation did not reduce the risk of all-cause mortality (RR, 0.86, 95% CI, 0.62-1.19, P=0.36; I2=0), stroke (RR, 0.55, 95% CI, 0.18-1.66, P=0.29; I2=0), need for cardioversion (RR, 0.84, 95% CI, 0.66-1.08, P=0.17; I2=0) or pacemaker (RR, 0.59, 95% CI, 0.34-1.01, P=0.06; I2=0). However, ablation reduced the RR of cardiac hospitalization (0.37, 95% CI, 0.18-0.77, P=0.01; I2=86), and recurrent atrial arrhythmia (0.46, 95% CI, 0.35-0.60, P |
| Databáze: | OpenAIRE |
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