Solid hemoglobin-polymer phantoms for evaluation of biophotonic systems
| Autor: | T. Joshua Pfefer, Yu Chen, Hyounguk Jang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Materials science medicine.diagnostic_test Absorption spectroscopy Optical Phenomena Spectrophotometry Infrared business.industry Phantoms Imaging Sonication Optical Imaging Silicones Hyperspectral imaging Polymer Atomic and Molecular Physics and Optics Optical phenomena chemistry.chemical_compound Hemoglobins Optics Silicone chemistry Spectrophotometry Attenuation coefficient medicine business |
| Zdroj: | Optics letters. 40(18) |
| ISSN: | 1539-4794 |
| Popis: | Stable tissue phantoms that incorporate the spectral absorption properties of hemoglobin would benefit a wide range of biophotonic technologies. Toward this end, we have developed and validated a novel polymer material incorporating hemoglobin. Our solid hemoglobin-polymer (SHP) material is fabricated by mixing liquid silicone base with a hemoglobin solution, followed by sonication and low temperature curing. The optical properties of samples were determined over 450-1000 nm using the inverse adding-doubling method and the Beer-Lambert law. Measurements indicated SHP optical stability over four months. Near-infrared spectroscopy and hyperspectral imaging measurements of SHP samples were performed to demonstrate the utility of this approach. SHP materials have the potential to improve tissue-simulating phantoms used for development, evaluation, and standardization of optical devices for oximetry and other applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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