Regulatory T-lymphocytes in asthma
| Autor: | A. J. M. Van Oosterhout, Nanne Bloksma |
|---|---|
| Přispěvatelé: | Immunofarmacologie van het respiratoire en gastrointestinale systemen, Universiteit Utrecht, Dep Farmaceutische wetenschappen, Dep Biologie |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cell type Allergen immunotherapy Allergy IMMUNOLOGICAL SELF-TOLERANCE Regulatory T cell medicine.medical_treatment INTESTINAL BACTERIAL-FLORA Immunology chemical and pharmacologic phenomena Biomedische technologie en medicijnen T-Lymphocytes Regulatory INDUCED AIRWAY HYPERREACTIVITY Farmacie/Biofarmaceutische wetenschappen (FARM) hygiene Immune system medicine Animals Humans regulatory T-cell IL-2 receptor Lung T-helper cell type 2 Pharmacology TOLL-LIKE RECEPTORS TRANSCRIPTION FACTOR FOXP3 business.industry Farmacie(FARM) Models Immunological MEDIATED ALLERGIC INFLAMMATION TOLEROGENIC DENDRITIC CELLS GRASS-POLLEN IMMUNOTHERAPY TGF-BETA Immunotherapy T-Lymphocytes Helper-Inducer asthma medicine.disease allergy Overig medisch onderzoek Immunity Innate medicine.anatomical_structure INDUCED TNF RECEPTOR Cytokines immunotherapy business CD8 |
| Zdroj: | European Respiratory Journal. 26(5):918-932 |
| ISSN: | 0903-1936 |
| DOI: | 10.1183/09031936.05.00011205 |
| Popis: | T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept of a disturbed Th1/Th2 balance, although having furthered the present understanding of immunoregulation in asthma, has recently been named a "procrustean paradigm", because of its failure to adequately explain many (pre)clinical observations. In recent years, the general knowledge regarding the regulation of infectious, autoimmune diseases, asthma and allergen immunotherapy by T-regulatory (Treg) cells, has rapidly increased. Many different Treg subsets have been described, including CD8+ Treg cells, natural killer (NK) cells and several different CD4+ Treg cell subsets. In this review, the authors will focus on two major and well-described CD4+ Treg cell subsets. In this review, the authors will focus on two major and well-described CD4+ Treg cell subsets. These consist of naturally occurring CD25+ Treg cells and adaptive Treg cells that are postulated to prevent immune responses against self-antigens and adaptive immune responses, respectively. The adaptive T-regulatory cells are further subdivided into T-regulatory cells type 1 and T-helper cell type 3 that mediate suppression exclusively via the cytokines interleukin-10 and transforming growth factor-beta, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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