Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma
| Autor: | F. Gallardo, Buenaventura Hernández-Machín, A. Pérez Gil, Andrea Combalia, R. Izu, R.M. Pujol, Cristina Muniesa, M P García Muret, Javier Cañueto, Jesús Bastida, Ricardo Fernández-de-Misa, L. Blanch Rius, M. Morillo, Lidia Maroñas-Jiménez, Pablo L. Ortiz-Romero, Yeray Peñate, Ariadna Ortiz-Brugués, Rosa M. Martí, M. Blanes, P. Espinosa Lara, S. Pérez Gala, Teresa Estrach, Octavio Servitje, Concepción Román |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty CD30 medicine.medical_treatment Primary cutaneous anaplastic large cell lymphoma Dermatology Gastroenterology Cutaneous lymphoma 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Lymphoma Primary Cutaneous Anaplastic Large Cell hemic and lymphatic diseases Internal medicine medicine Humans In patient Neoplasm Staging Retrospective Studies Chemotherapy business.industry Large cell Middle Aged medicine.disease Prognosis Lymphoma Radiation therapy Survival Rate Infectious Diseases Spain 030220 oncology & carcinogenesis Lymphatic Metastasis Disease Progression Female business |
| Zdroj: | JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| ISSN: | 0926-9959 |
| Popis: | BACKGROUND Reliable prognostic factors for patients with primary cutaneous anaplastic large cell lymphoma (PCALCL) are lacking. OBJECTIVE To identify prognostic factors for specific survival in patients with PCALCL. METHODS Using the convenience sampling method, patients with PCALCL diagnosed from May 1986 to August 2017 in 16 University Departments were retrospectively reviewed. RESULTS One hundred eight patients were included (57 males). Median age at diagnosis was 58 years. All of them showed T1-3N0M0 stages. Seventy per cent of the cases presented with a solitary lesion, mostly at the limbs. Complete response rate after first-line treatment was 87%, and no advantage was observed for any of them (surgery, radiotherapy, chemotherapy or other approaches). Nodal and visceral progression rate was 11% and 2%, respectively. 5-year specific survival (SSV) reached 93%; 97% for T1 patients and 84% for T2/T3 patients (P = 0.031). Five-year SSV for patients developing early cutaneous relapse was 64%; for those with late or no relapse, 96% (P = 0.001). Estimated median SSV for patients showing nodal progression was 103 months (95% CI: 51-155 months); for patients without nodal progression, estimated SSV did not reach the median (P |
| Databáze: | OpenAIRE |
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