Distribution of espI among clinical enterohaemorrhagic and enteropathogenic Escherichia coli isolates
| Autor: | Gad Frankel, Henry R. Smith, Rosanna Mundy, Claire Jenkins, Jun Yu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Diarrhea
Microbiology (medical) Genomic Islands Virulence Factors Prophages Virulence Biology medicine.disease_cause digestive system Microbiology London Escherichia coli medicine Humans Serotyping Enteropathogenic Escherichia coli Adhesins Bacterial Escherichia coli Infections Prophage Intimin Antigens Bacterial Molecular Epidemiology Effector Escherichia coli Proteins O Antigens General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses Pathogenicity island Virology Bacterial adhesin Hemolytic-Uremic Syndrome bacteria |
| Zdroj: | Journal of Medical Microbiology. 53:1145-1149 |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Enterohaemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli are important diarrhoeagenic pathogens; infection is dependent on translocation of a number of type III effector proteins. Until recently all the known effectors were encoded on the LEE pathogenicity island, which also encodes the adhesin intimin and the type III secretion apparatus. Recently, a novel non-LEE effector protein, EspI/NleA, which is required for full virulence in vivo and is encoded on a prophage, was identified. The aim of this study was to determine the distribution of espI among clinical EHEC and EPEC isolates. espI was detected in 86 % and 53 % of LEE+ EHEC and EPEC strains, respectively. Moreover, the espI gene was more commonly found in patients suffering from a more severe disease. |
| Databáze: | OpenAIRE |
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