White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposure
| Autor: | Gary S. Skrinar, Janet E. Staab, Charles S. Fulco, Allen Cymerman, Stephen R. Muza, S. F. Lewis, Beth A. Beidleman, Michael N. Sawka |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Hydrocortisone medicine.drug_class Lymphocyte Acclimatization Physical exercise Biology Leukocyte Count Norepinephrine Internal medicine White blood cell medicine Leukocytes Humans Blood Specimen Collection Altitude General Medicine Hormones Endocrinology medicine.anatomical_structure Catecholamine Exercise Test Corticosteroid Female medicine.drug |
| Zdroj: | Clinical science (London, England : 1979). 111(2) |
| ISSN: | 0143-5221 |
| Popis: | Recent studies have demonstrated that brief daily IAE (intermittent altitude exposure) was equally as effective as continuous altitude residence in inducing physiological adaptations consistent with altitude acclimatization. Although the positive benefits of IAE have been clearly defined, the potential negative consequences of IAE on health, specifically the immune system, remain undefined. The present study determined the effects of IAE on WBC (white blood cell) and hormonal responses during rest and exercise at 4300 m altitude. Six lowlanders (age, 23±2 years; body weight, 77±6 kg; values are means±S.E.M.) completed a V̇O2max (maximal O2 uptake) and submaximal cycle ergometer test during a 30-h SL (sea level) exposure and during a 30 h exposure to 4300 m altitude-equivalent once before (PreIAE) and once after (PostIAE) a 3-week period of IAE (4 h·day−1, 5 days·week−1, 4300 m). The submaximal cycle ergometer test consisted of two consecutive 15-min work bouts at 40% and 70% of altitude-specific V̇O2max. Blood samples were obtained at rest and during both exercise work bouts for measurements of WBC count, leucocyte subset counts, cortisol, adrenaline (epinephrine) and noradrenaline (norepinephrine). WBC, neutrophil and lymphocyte counts increased significantly (P |
| Databáze: | OpenAIRE |
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