Plasma renin activity and plasma catecholamines in intact and splenectomized running and swimming beagle dogs
| Autor: | A. C. M. Schrikker, J. M. den Hertog, W. J. Kraan, G. H. Huisman, F. W. van Schaik, J. A. Joles |
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| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Physiology medicine.medical_treatment Splenectomy Hematocrit Beagle Plasma renin activity Running Norepinephrine Catecholamines Dogs Physiology (medical) Internal medicine Renin–angiotensin system Renin medicine Animals Orthopedics and Sports Medicine Swimming medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health Radioimmunoassay General Medicine Endocrinology Renal blood flow Catecholamine Female business Spleen medicine.drug |
| Zdroj: | European journal of applied physiology and occupational physiology. 49(1) |
| ISSN: | 0301-5548 |
| Popis: | The influence of splenectomy in the dog on plasma catecholamine levels and plasma renin activity during treadmill running and swimming was investigated. Plasma catecholamines were measured by a radioenzymatic assay and plasma renin activity by a radioimmunoassay. Exercise consistently increased plasma catecholamine levels before and after splenectomy (range of increase:3--38 pmol X ml-1). Swimming, however, was a stronger stimulus than running. No change in the ratio between noradrenaline and adrenaline was found. In intact dogs exercise results in a marked increase in hematocrit due to splenic contraction (range of increase 3--8 volume %), while renal blood flow and plasma renin activity remain virtually constant. In splenectomized dogs, exercise has been reported to induce a decrease in renal blood flow. In contrast to this known effect on renal blood flow, splenectomy did not affect plasma renin activity in treadmill running dogs. In swimming dogs, however, plasma renin activity was increased after splenectomy (range of increase 3.3--6.9 ng X Ang I X ml-1 X h-1). Possibly, a threshold in sympathetic tone is required to increase renin release in the dog. |
| Databáze: | OpenAIRE |
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