ESE audit on management of adult growth hormone deficiency in clinical practice
| Autor: | Luciana Martel-Duguech, Jens Otto L Jorgensen, Márta Korbonits, Gudmundur Johannsson, Susan M Webb, F Adamidou, G Mintziori, M Arosio, C Giavoli, C Badiu, M Boschetti, D Ferone, S Ricci Bitti, T Brue, F Albarel, S Cannavo, G Martino, O R Cotta, D Carvalho, D Salazar, E Christ, M Debono, T Dusek, R García, E Ghigo, V Gasco, M I Goth, D Olah, L Kovacs, C Höybye, T Kocjan, K Mlekuš Kozamernik, M Kužma, M Medic Stojanoska, A Novak, T Miličević, S Pekic, D Milijic, J Perez Luis, A Pico, V Preda, G Raverot, F Borson-Chazot, V Rochira, M L Monzani, K Sandahl, S Tsagarakis, V Mitravela, S Zacharieva, B Zilatiene, R Verkauskiene |
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| Přispěvatelé: | Universitat Autònoma de Barcelona (UAB), Starling House, Queen Mary University of London (QMUL), University of Gothenburg (GU), 'Hippokration' General Hospital of Thessaloniki, University of Milan, Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [Bethesda] (NIH), University of Genoa (UNIGE), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Marseille Maladies Rares (MarMaRa), Aix Marseille Université (AMU), Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM], University of Messina, Universidade do Porto, CHU Basel, Sheffield Teaching Hospitals, University Hospital Center Zagreb, Hospital General Universitario 'Gregorio Marañón' [Madrid], University of Turin, Hungarian Defense Forces, Karolinska University Hospital [Stockholm], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Comenius University in Bratislava, University Hospital Center Split, University of Belgrade [Belgrade], Universidad de La Laguna [Tenerife - SP] (ULL), University Miguel Hernández, Macquarie University, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Università degli Studi di Modena e Reggio Emilia, Aarhus University Hospital, Evangelismos Athens General Hospital, Medical University of Sofia [Bulgarie], Lithuanian University of health Sciences, Pfizer Independent Grant for Learning & Change: (IGLC): ID 9939445, Amadidou, Fotini, Mintziori, G, Arosio, Maura, Giavoli, Claudia, Badiu, Corin, Boschetti, Mara, Ferone, Diego, Ricci Bitti, Silvia, Brue, Thierry, Albarel, F, Cannavò, Salvatore, Cotta, Oana Ruxandra, Carvalho, Davide, Salazar, Daniela, Christ, Emanuel, Debono, Miguel, Dusek, Tina, Garcia-Centeno, Rogelio, Ghigo, Ezio, Gasco, Valentina, Góth, Miklós I, Oláh, Dóra, Kovacs, Laszlo, Höybye, Charlotte, Kocjan, Tomaz, Mlekuš Kozamernik, Katarina, Kužma, Martin, Payer, Juraj, Medic-Stojanoska, Milica, Novak, Anela, Miličević, Tanja, Pekic, Sandra, Miljic, Dragana, Perez Luis, Jesus, Pico, Antonio M, Preda, Veronica, Raverot, Gerald, Borson-Chazot, Francoise, Rochira, Vincenzo, Monzani, María Laura, Sandahl, Kristian, Tsagarakis, Stylianos, Mitravela, Vana, Zacharieva, Sabina, Žilaitienė, Birutė, Verkauskienė, Rasa, Università degli Studi di Milano = University of Milan (UNIMI), Università degli studi di Genova = University of Genoa (UniGe), Universidade do Porto = University of Porto, Università degli studi di Torino = University of Turin (UNITO), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Gall, Valérie |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Quality of life
medicine.medical_specialty Pediatrics Pituitary disease Endocrinology Diabetes and Metabolism Body compositition 030209 endocrinology & metabolism arginine Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology arginine clonidine glucagon growth hormone growth hormone releasing factor somatomedin C Pituitary adenoma 616.43 [udc] Internal medicine Health care medicine Hypopituytary Patients clonidine Reimbursement growth hormone releasing factor [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology business.industry Consensus Guidelines General Medicine Guideline medicine.disease somatomedin C GH Deficiency Craniopharyngioma 3. Good health Growth Hormone IGF-1 Growth Hormone Deficiency GHD AGHD glucagon 030220 oncology & carcinogenesis growth hormone Etiology Human growth hormone deficiency therapeutic use administration&dosage business Endocrine Society Quality of life Body compositition GH Deficiency Hypopituytary Patients Consensus Guidelines Endocrine Society [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology adult growth hormone deficiency diagnostics treatment guidelines |
| Zdroj: | European Journal of Endocrinology European Journal of Endocrinology, BioScientifica, 2021, 184 (2), pp.323-334. ⟨10.1530/eje-20-1180⟩ Martel-Duguech, L M, Jorgensen, J O L, Korbonits, M, Johannsson, G, Webb, S M & European Society of Endocrinology 2021, ' ESE audit on management of Adult Growth Hormone Deficiency in clinical practice ', European Journal of Endocrinology, vol. 184, no. 2, pp. 323-334 . https://doi.org/10.1530/EJE-20-1180 EUROPEAN JOURNAL OF ENDOCRINOLOGY r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname European journal of endocrinology, Bristol : BioScientifica Ltd, 2020, vol. 00, no. 00, p. 1-40 European Journal of Endocrinology, 2021, 184 (2), pp.323-334. ⟨10.1530/eje-20-1180⟩ |
| ISSN: | 0804-4643 1479-683X |
| Popis: | Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. Aims (1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; (2) To evaluate educational status of healthcare professionals about AGHD. Design Online survey in endocrine centres throughout Europe. Patients and methods Endocrinologists voluntarily completed an electronic questionnaire regarding AGHD patients diagnosed or treated in 2017–2018. Results Twenty-eight centres from 17 European countries participated, including 2139 AGHD patients, 28% of childhood-onset GHD. Aetiology was most frequently non-functioning pituitary adenoma (26%), craniopharyngioma (13%) and genetic/congenital midline malformations (13%). Diagnosis of GHD was confirmed by a stimulation test in 52% (GHRH+arginine: 45%; insulin-tolerance: 42%, glucagon: 6%; GHRH alone and clonidine tests: 7%); in the remaining, ≥3 pituitary deficiencies and low serum IGF-I were diagnostic. Initial GH dose was lower in older patients, but only women Conclusion Despite guideline recommendations, GH replacement in AGHD is still not available or reimbursed in all European countries. Knowledge among professionals and health administrators needs improvement to optimise the care of adults with GHD. |
| Databáze: | OpenAIRE |
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