Functional response to inhaled salbutamol and/or ipratropium bromide in Ascaris suum-sensitised cats with allergen-induced bronchospasms
| Autor: | Carole Cambier, Cécile Clercx, Jérôme Leemans, Pascal Gustin, Nathalie Kirschvink |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Ipratropium bromide Cat Diseases Bronchospasm Administration Inhalation Animals Medicine Albuterol Ascaris suum Asthma Feline asthma Cross-Over Studies Bronchial Spasm General Veterinary Inhalation business.industry Ipratropium Inhaler Allergens respiratory system medicine.disease Crossover study Bronchodilator Agents Treatment Outcome Anesthesia Cats Salbutamol Drug Therapy Combination Female Animal Science and Zoology medicine.symptom business medicine.drug |
| Zdroj: | The Veterinary Journal. 186:76-83 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2009.07.021 |
| Popis: | Knowledge about the use of inhaled bronchodilators in cats with so-called 'feline asthma' is limited and relies on the experience of clinicians treating these patients. A randomised controlled four-way crossover study was therefore designed to compare the effects of salbutamol (SAL, 100 μg), ipratropium bromide (IB, 20 μg) and a combination of both (SAL/IB, 100 μg/20 μg), delivered through a pressurised metered-dose inhaler (pMDI) connected to a spacing chamber, on allergen-induced bronchospasms in five Ascaris suum (AS)-sensitised cats. Four AS bronchial provocation challenges were carried out at 1 week intervals, followed by one of four treatment protocols: SAL, IB, SAL/IB or control (untreated). Enhanced pause (Penh), an estimator of airflow limitation measured by barometric whole-body plethysmography, was repeatedly assessed within 120 min following the administration of each treatment protocol. Responses to inhaled medications were evaluated by calculating the area under the time-response curves (AUC) from 0 to 60 or 120 min after drug administration (AUC(0-60), AUC(0-120)), as well as the times required for half-recovery (T(50%)) or for returning to nearly basal conditions (T(20%)). No significant differences were found among the four study groups, with reference to the mean AUC(0-60), T(20%) and T(50%) values of Penh (P0.05). Mean AUC(0-120) values of Penh were similar between the bronchodilators tested, but were significantly lower than those in the untreated group. It was concluded that inhalation of SAL, IB and SAL/IB via pMDI failed to improve most Penh-derived parameters, which suggested that these bronchodilators were of limited efficacy in reversing allergen-induced bronchospasm in cats. However, further studies using a larger number of animals are warranted to investigate if different drugs or delivery devices or higher dosages may be more effective. |
| Databáze: | OpenAIRE |
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