Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome
| Autor: | Yutong Su, Qiongyi Hu, Gary L. Norman, Xue-Feng Wang, Hui Zheng, Hui Shi, Huiyun Gong, Honglei Liu, Jialin Teng, Yi-Bing Peng, Yufeng Yin, Xinyao Wu, Jinfeng Zhou, Xin-Ming Shi, Chengde Yang, Yue Sun, Xiaobing Cheng, Junna Ye |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male China medicine.medical_specialty Clinical Biochemistry Phosphatidylserines 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Pregnancy Risk Factors Antiphospholipid syndrome Internal medicine medicine Humans Venous Thrombosis 030203 arthritis & rheumatology Ankylosing spondylitis Lupus anticoagulant biology business.industry Biochemistry (medical) General Medicine Odds ratio Antiphospholipid Syndrome medicine.disease Thrombosis Obstetric Labor Complications Venous thrombosis Rheumatoid arthritis Antibodies Antiphospholipid biology.protein Female Prothrombin Antibody business Biomarkers |
| Zdroj: | Clinical Chemistry and Laboratory Medicine (CCLM). 56:614-624 |
| ISSN: | 1437-4331 1434-6621 |
| Popis: | Background: The aim of the study was to determine the prevalence and clinical associations of antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis and pregnancy loss in Chinese patients with antiphospholipid syndrome (APS) and seronegative APS (SNAPS). Methods: One hundred and eighty six Chinese patients with APS (67 primary, 119 secondary), 48 with SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s syndrome [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) and 90 healthy donors were examined. IgG and IgM aPS/PT, IgG/IgM/IgA anticardiolipin (aCL) and IgG/IgM/IgA anti-β2-glycoprotein I (anti-β2GPI) antibodies were tested by ELISA. Results: One hundred and sixty (86.0%) of APS patients were positive for at least one aPS/PT isotype. One hundred and thirty five (72.6%) were positive for IgG aPS/PT, 124/186 (66.7%) positive for IgM aPS/PT and 99 (53.2%) positive for both. Approximately half of the SNAPS patients were positive for IgG and/or IgM aPS/PT. Highly significant associations between IgG aPS/PT and venous thrombotic events (odds ratio [OR]=6.72) and IgG/IgM aPS/PT and pregnancy loss (OR=9.44) were found. Levels of IgM aPS/PT were significantly different in APS patients with thrombotic manifestations and those with fetal loss (p=0.014). The association between IgG/IgM aPS/PT and lupus anticoagulant (LAC) was highly significant (p Conclusions: Anti-PS/PT antibody assays demonstrated high diagnostic performance for Chinese patients with APS, detected some APS patients negative for criteria markers and may serve as potential risk predictors for venous thrombosis and obstetric complications. |
| Databáze: | OpenAIRE |
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