Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone
| Autor: | Judy Natalia Jiménez, Daniela Fortini, Andrea Endimiani, Sylvain Brisse, Claudia Feudi, Ana M. Ocampo, Caterina Mammina, Celestino Bonura, Virginie Passet, Michel Doumith, Neil Woodford, Katie L. Hopkins, Laura Villa, Alessandra Carattoli |
|---|---|
| Přispěvatelé: | Villa, Laura, Feudi, Claudia, Fortini, Daniela, Brisse, Sylvain, Passet, Virginie, Bonura, Celestino, Endimiani, Andrea, Mammina, Caterina, Ocampo, Ana Maria, Jimenez, Judy Natalia, Doumith, Michel, Woodford, Neil, Hopkins, Katie, Carattoli, Alessandra |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Settore MED/07 - Microbiologia E Microbiologia Clinica siderophore antibiotic resistance long term survival sequence analysis Klebsiella pneumoniae polymerase chain reaction Responses to Human Interventions Drug Resistance Gene Transfer Clone (cell biology) ST259 bacterial protein virulence factor Yersiniabactin Genome chemistry.chemical_compound Microbial Plasmid Antibiotics bacterial genome pathogenicity genetics 610 Medicine & health genome analysis Cross Infection Molecular Epidemiology Virulence biology drug effect yersiniabactin Bacterial Drug Resistance Microbial General Medicine Klebsiella infection glycogen synthesis England Italy ST307 horizontal gene transfer Proteínas Bacterianas Research Article Gene Transfer Horizontal Virulence Factors Sequence analysis capsule 030106 microbiology pulsed field gel electrophoresis Colombia Carbapenemase beta lactamase virulence factor antibiotic resistance Article bacterial strain bacterial virulence bacterium isolate fimbria microbial diversity nonhuman plasmid whole genome sequencing carbapenem-resistant Enterobacteriaceae cross infection genetic variation human microbiology molecular epidemiology multilocus sequence typing virulence Bacterial Proteins beta-Lactamases Carbapenem-Resistant Enterobacteriaceae Genetic Variation Genome Bacterial Humans Klebsiella Infections Multilocus Sequence Typing Whole Genome Sequencing Horizontal Microbiology 03 medical and health sciences Antibiotic resistance Bacterial Proteins Infecciones por Klebsiella biology.organism_classification Enterobacteriaceae Resistentes a los Carbapenémicos KPC 030104 developmental biology chemistry Epidemiología Molecular WGS |
| Zdroj: | Microbial Genomics Repositorio UdeA Universidad de Antioquia instacron:Universidad de Antioquia Villa, Laura; Feudi, Claudia; Fortini, Daniela; Brisse, Sylvain; Passet, Virginie; Bonura, Celestino; Endimiani, Andrea; Mammina, Caterina; Ocampo, Ana Maria; Jimenez, Judy Natalia; Doumith, Michel; Woodford, Neil; Hopkins, Katie; Carattoli, Alessandra (2017). Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone. Microbial genomics, 3(4) Microbiology Society 10.1099/mgen.0.000110 |
| DOI: | 10.1099/mgen.0.000110 |
| Popis: | The global spread of Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase (KPC) has been mainly associated with the dissemination of high-risk clones. In the last decade, hospital outbreaks involving KPC-producing K. pneumoniae have been predominantly attributed to isolates belonging to clonal group (CG) 258. However, results of recent epidemiological analysis indicate that KPC-producing sequence type (ST) 307, is emerging in different parts of the world and is a candidate to become a prevalent high-risk clone in the near future. Here we show that the ST307 genome encodes genetic features that may provide an advantage in adaptation to the hospital environment and the human host. Sequence analysis revealed novel plasmid-located virulence factors, including a cluster for glycogen synthesis. Glycogen production is considered to be one of the possible adaptive responses to long-term survival and growth in environments outside the host. Chromosomally-encoded virulence traits in the clone comprised fimbriae, an integrative conjugative element carrying the yersiniabactin siderophore, and two different capsular loci. Compared with the ST258 clone, capsulated ST307 isolates showed higher resistance to complement-mediated killing. The acquired genetic features identified in the genome of this new emerging clone may contribute to increased persistence of ST307 in the hospital environment and shed light on its potential epidemiological success. COL0126131 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|